Our work is directed at understanding the mechanisms that govern the structure and function of chromosomes in all kingdoms of life. We approach problems in chromosome biology using a wide variety of experimental systems (yeasts, frogs, humans, archaea, dinoflagellates) and employing diverse approaches (biochemistry, biophysics, functional genomics, cell biology, microscopy, and computation). We are interested in how cells accurately segregate chromosomes to daughter cells during mitosis and meiosis to produce viable daughters and gametes so that an organism can grow, develop and proliferate. We also investigate how stable states are generated and maintained in chromosomes to control the functions of chromosomal domains. Our research has focused on understanding how the chromosomal centromere and kinetochore are assembled and function to support cell division and how the repetitive regions of the genome are regulated by heterochromatin. We are interested in the mechanisms through which chromosome associated RNA regulates epigenetic states and how chromosomes are structured in interphase and mitosis.
Our work is directed at understanding the mechanisms that govern the structure and function of chromosomes in all kingdoms of life. We approach problems in chromosome biology using a wide variety of experimental systems (yeasts, frogs, humans, archaea, dinoflagellates) and employing diverse approaches (biochemistry, biophysics, functional genomics, cell biology, microscopy, and computation). We are interested in how cells accurately segregate chromosomes to daughter cells during mitosis and meiosis to produce viable daughters and gametes so that an organism can grow, develop and proliferate. We also investigate how stable states are generated and maintained in chromosomes to control the functions of chromosomal domains. Our research has focused on understanding how the chromosomal centromere and kinetochore are assembled and function to support cell division and how the repetitive regions of the genome are regulated by heterochromatin. We are interested in the mechanisms through which chromosome associated RNA regulates epigenetic states and how chromosomes are structured in interphase and mitosis.
Our work is directed at understanding the mechanisms that govern the structure and function of chromosomes in all kingdoms of life. We approach problems in chromosome biology using a wide variety of experimental systems (yeasts, frogs, humans, archaea, dinoflagellates) and employing diverse approaches (biochemistry, biophysics, functional genomics, cell biology, microscopy, and computation). We are interested in how cells accurately segregate chromosomes to daughter cells during mitosis and meiosis to produce viable daughters and gametes so that an organism can grow, develop and proliferate. We also investigate how stable states are generated and maintained in chromosomes to control the functions of chromosomal domains. Our research has focused on understanding how the chromosomal centromere and kinetochore are assembled and function to support cell division and how the repetitive regions of the genome are regulated by heterochromatin. We are interested in the mechanisms through which chromosome associated RNA regulates epigenetic states and how chromosomes are structured in interphase and mitosis.